Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats
Abstract
Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic lymphocyte phenotypes and the inflammatory cytokine expression in male F344 rats. Exposure of animals to AFB1 [5-75 µg kg(-1) body weight (BW)] for …
Keywords
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
N.I.H.
Extramural
Rats
phenotype
dose-response relationship
drug
flow cytometry
oral
lymphocytes / immunology
spleen / immunology
cytokines / biosynthesis*
killer cells
t-lymphocyte subsets / immunology
b-lymphocytes / immunology
pmid:23508487
pmc4268892
doi:10.1002/jat.2866
guoqing qian
lili tang
jia-sheng wang
aflatoxin b1 / toxicity*
b-lymphocytes / drug effects
environmental pollutants / toxicity*
natural / drug effects
natural / immunology
lymphocytes / drug effects*
inbred f344
spleen / drug effects*
t-lymphocyte subsets / drug effects
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271437
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