In vitro and in vivo sensitivity of a non-mouse-adapted influenza A (Beijing) virus infection to amantadine and ribavirin
Abstract
A clinically isolated non-mouse-adapted influenza A/Beijing/32/92 virus was assayed for sensitivity to amantadine and ribavirin in vitro and in mice. When multiple concentrations of each drug were assayed for ability to inhibit the virus-induced cytopathic effect in MDCK cells, the 50% effective (vi …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
female
P.H.S.
Inbred BALB C
antiviral agents / therapeutic use*
ribavirin / therapeutic use*
influenza a virus / drug effects*
oxygen / blood
ribavirin / pharmacology
orthomyxoviridae infections / drug therapy*
amantadine / pharmacology
amantadine / therapeutic use*
pmid:8529436
doi:10.1159/000239382
r w sidwell
k w bailey
j h huffman
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271385
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