Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques
Abstract
We investigated the prophylactic and therapeutic efficacy of an intravenous (IV) formulation of zanamivir in a macaque infection model for highly pathogenic influenza A (H5N1) virus. Antiviral efficacy was dose-dependent, with no reduction in viral load observed at 2 mg/kg, but a significant reducti …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
male
Disease Models
Animal
Comparative Study
influenza
human / drug therapy*
human / prevention & control
antiviral agents / administration & dosage*
influenza a virus
human / virology
h5n1 subtype / physiology
pmid:18647621
doi:10.1016/j.antiviral.2008.06.014
k j stittelaar
m tisdale
a d m e osterhaus
h5n1 subtype / drug effects*
macaca
zanamivir / administration & dosage*
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