Neuropathological assessment of artemether-treated severe malaria
Abstract
In animals, high doses of intramuscular artemether and artemotil have been shown to cause an unusual pattern of selective damage to certain brainstem nuclei, especially those implicated in hearing and balance. We aimed to investigate whether a similar pattern arises in human adults. We examined the …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
adult
female
male
Comparative Study
malaria
antimalarials / therapeutic use
quinine / therapeutic use
falciparum / pathology
falciparum / drug therapy*
antimalarials / adverse effects*
artemether
sesquiterpenes / adverse effects*
sesquiterpenes / therapeutic use
pmid:12892962
doi:10.1016/s0140-6736(03)13974-8
t t hien
g d h turner
n j white
artemisinins / adverse effects*
artemisinins / therapeutic use
brain diseases / chemically induced*
brain diseases / pathology*
brain stem / drug effects
brain stem / pathology
quinine / adverse effects
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271340
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