A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
Abstract
The S. cerevisiae MCD1 (mitotic chromosome determinant) gene was identified in genetic screens for genes important for chromosome structure. MCD1 is essential for viability and homologs are found from yeast to humans. Analysis of the mcd1 mutant and cell cycle-dependent expression pattern of Mcd1p s …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
RNA
gene expression regulation
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Genes
mutation
sequence homology
amino acid
chromosomes
messenger / analysis
cell cycle proteins / genetics
cell division
fungal / genetics
saccharomyces cerevisiae / genetics*
chromosomal proteins
fungal / physiology*
cell cycle proteins / physiology*
v guacci
d koshland
fungal / analysis
fungal proteins / genetics
fungal / physiology
phosphoproteins
saccharomyces cerevisiae proteins
chromatids / physiology*
pmid:9335334
pmc2670185
doi:10.1016/s0092-8674(01)80008-8
a strunnikov
cell cycle proteins / analysis
cell nucleus / chemistry
non-histone*
nuclear proteins
recombinant fusion proteins
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271145
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