Structural basis for the activation of cholera toxin by human ARF6-GTP
Abstract
The Vibrio cholerae bacterium causes devastating diarrhea when it infects the human intestine. The key event is adenosine diphosphate (ADP)-ribosylation of the human signaling protein GSalpha, catalyzed by the cholera toxin A1 subunit (CTA1). This reaction is allosterically activated by human ADP-ri …
Keywords
Evolution
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Molecular
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
u.s. gov't
N.I.H.
Extramural
amino acid sequence
P.H.S.
Molecular Sequence Data
protein conformation
protein binding
protein structure
binding sites
secondary
x-ray
crystallography
pmid:16099990
doi:10.1126/science.1113398
claire j o'neal
michael g jobling
wim g j hol
adp-ribosylation factors / chemistry*
adp-ribosylation factors / genetics
adp-ribosylation factors / metabolism*
cholera toxin / chemistry*
cholera toxin / genetics
cholera toxin / metabolism*
dimerization
guanosine diphosphate / metabolism
guanosine triphosphate / chemistry*
guanosine triphosphate / metabolism*
hydrophobic and hydrophilic interactions
nad / metabolism
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271079
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