Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
Abstract
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R), was originally purified from the rat stomach. Like the synthetic GHSs, ghrelin specifically releases GH following intravenous administration. Also consistent with the central actions of GHSs, ghrelin-immunoreactive c …
Keywords
injections
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Rats
in situ hybridization
messenger / analysis
proteins / genetics
hypothalamus / metabolism*
j kamegai
h tamura
i wakabayashi
agouti-related protein
eating / drug effects
ghrelin
hypothalamus / drug effects
intraventricular
intercellular signaling peptides and proteins
peptide hormones*
peptides / administration & dosage*
peptides / pharmacology
pituitary gland / metabolism
pmid:11108296
doi:10.1210/endo.141.12.7920
arcuate nucleus of hypothalamus / chemistry
gene expression / drug effects*
growth hormone / metabolism
neuropeptides / genetics*
pituitary gland / drug effects
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271064
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