The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
Abstract
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading frames. The product of the alpha transcript, p16(INK4a), is a recognized tumour suppressor that induces a G1 cell cycle arrest by inhibiting the phosphorylation of the ret …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
gene expression regulation
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
u.s. gov't
amino acid sequence
Comparative Study
P.H.S.
neoplastic*
Molecular Sequence Data
sequence homology
amino acid
protein binding
proteins / genetics
feedback
cyclin-dependent kinase inhibitor p16 / genetics
nuclear proteins*
proteins / metabolism*
Tumor Suppressor Protein p14ARF
proto-oncogene proteins / metabolism*
proto-oncogene proteins c-mdm2
tumor suppressor protein p53 / metabolism*
cell cycle / physiology
pmid:9724636
pmc1170828
doi:10.1093/emboj/17.17.5001
f j stott
s bates
g peters
alternative splicing*
cyclin-dependent kinase inhibitor p16 / metabolism*
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271016
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