Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion

Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion

Rolef Ben-Shahar T;Heeger S;Lehane C;East P;Flynn H;Skehel M;Uhlmann F;;
Science (New York, N.Y.) 2008 Vol. 321 pp. -
242
t2008scienceeco1-dependent

Abstract

Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensi …

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