Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices
Abstract
Here we show that endothelial cells (EC) require matrix type 1-metalloproteinase (MT1-MMP) for the formation of lumens and tube networks in 3-dimensional (3D) collagen matrices. A fundamental consequence of EC lumen formation is the generation of vascular guidance tunnels within collagen matrices th …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
N.I.H.
Extramural
Cells
Cultured
substrate specificity
biocatalysis
pmid:19339693
pmc2714200
doi:10.1182/blood-2008-12-196451
amber n stratman
w brian saunders
george e davis
blood vessels / enzymology*
collagen / metabolism*
endothelial cells / cytology
endothelial cells / enzymology*
matrix metalloproteinase 14 / genetics
matrix metalloproteinase 14 / metabolism*
small interfering / genetics
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270915
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