Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits
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Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits

Wan Yun Ho, Ira Agrawal, Sheue-Houy Tyan, Emma Sanford, Wei-Tang Chang, Kenneth Lim, Jolynn Ong, Bernice Siu Yan Tan, Aung Aung Kywe Moe, Regina Yu, Peiyan Wong, Greg Tucker-Kellogg, Edward Koo, Kai-Hsiang Chuang, Shuo-Chien Ling;Wan Yun Ho;Ira Agrawal;Sheue-Houy Tyan;Emma Sanford;Wei-Tang Chang;Kenneth Lim;Jolynn Ong;Bernice Siu Yan Tan;Aung Aung Kywe Moe;Regina Yu;Peiyan Wong;Greg Tucker-Kellogg;Edward Koo;Kai-Hsiang Chuang;Shuo-Chien Ling;
acta neuropathologica communications 2021 Vol. 9 pp. -
181
ling2021actadysfunction

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of the same disease spectrum of adult-onset neurodegenerative diseases that affect the motor and cognitive functions, respectively. Multiple common genetic loci such ...

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DOI:
10.1186/s40478-020-01111-4
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC77894...

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