Identification of sequence changes in myosin II that adjust muscle contraction velocity
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Identification of sequence changes in myosin II that adjust muscle contraction velocity

Chloe A. Johnson;Jake E. McGreig;Sarah T. Jeanfavre;Jonathan Walklate;Carlos D. Vera;Marta Farré;Daniel P. Mulvihill;Anthony J. Baines;Martin Ridout;Leslie A. Leinwand;Mark N. Wass;Michael A. Geeves;
plos biology 2021 Vol. 19 pp. e3001248-
162
johnson2021plosidentification

Abstract

Heart and skeletal muscles of larger mammals contract more slowly than smaller ones. This study identifies amino acid changes in myosin isoforms that correlate with species size; mutating the residues in human β-myosin to match the rat sequence at these positions increased its in vitro velocity to that of the rat protein.

Keywords

phylogenetic analysis mammals protein sequencing muscle contraction amino acid analysis myosins cardiac muscles cardiomyopathies

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DOI:
10.1371/journal.pbio.3001248
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https://journals.plos.org/plosbiology/article?id=1...

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ID: 270752
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