Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment
Abstract
Prenatal testosterone (T) excess during midgestation leads to estrous cycle defects and polycystic ovaries in sheep. We hypothesized that follicular persistence causes polycystic ovaries and that cyclic progesterone (P) treatment would overcome follicular persistence and restore cyclicity. Twice-wee …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
female
N.I.H.
Extramural
sexual maturation / drug effects
ovulation / drug effects
progesterone / blood
testosterone / toxicity*
sheep
fetus / drug effects*
progesterone / pharmacology*
ovarian follicle / physiology
mohan manikkam
vasantha padmanabhan
pmid:16373416
doi:10.1210/en.2005-1338
teresa l steckler
estrus / drug effects
luteal phase / drug effects
ovarian follicle / drug effects*
polycystic ovary syndrome / etiology
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270731
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