Enforced proximity in the function of a famous scaffold
Abstract
Recent studies by Park, Zarrinipar, and Lim with reengineered Ste5 scaffold proteins underscore the fundamental importance of proximity in enzyme regulation and of keeping a proper distance for maintaining signaling specificity.
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
pubmed abstract
nih
national institutes of health
national library of medicine
models
Genes
mutation
biological
carrier proteins / genetics
signal transduction
saccharomyces cerevisiae / genetics
adaptor proteins
saccharomyces cerevisiae / chemistry
saccharomyces cerevisiae proteins / physiology*
saccharomyces cerevisiae proteins / genetics
saccharomyces cerevisiae / physiology
fungal
pmid:12620218
doi:10.1016/s1097-2765(03)00055-8
james e ferrell
karlene a cimprich
signal transducing*
carrier proteins / physiology*
protein engineering
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270698
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