Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Abstract
By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-c …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Comparative Study
signal transduction*
Receptors
mutation
transgenic
trans-activators / metabolism*
bone morphogenetic protein receptors
type i
mutant strains
wnt proteins
beta catenin
cytoskeletal proteins / metabolism*
proto-oncogene proteins / metabolism*
protein-serine-threonine kinases / metabolism
zebrafish proteins*
trans-activators / genetics
body patterning / genetics
cytoskeletal proteins / genetics
pmid:12923052
pmc196251
doi:10.1101/gad.263003
natalia soshnikova
dietmar zechner
walter birchmeier
ectoderm / metabolism
extremities / embryology*
fibroblast growth factor 8
fibroblast growth factors / metabolism
hindlimb / abnormalities
limb deformities
congenital / genetics
growth factor / metabolism*
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270670
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