Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fates

Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fates

Suzanne L. Mansour, Chaoying Li, Lisa D. Urness;Suzanne L. Mansour;Chaoying Li;Lisa D. Urness;
genes & development 2013 Vol. 27 pp. 2320-
168
urness2013genesgenetic

Abstract

The stereotyped arrangement of cochlear sensory and supporting cells is critical for auditory function. Our previous studies showed that Muenke syndrome model mice (Fgfr3[P244R/+] ) have hearing loss associated with a supporting cell fate transformation ...

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