Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers
Abstract
Zanamivir is a well tolerated drug. The low level of absorption of the drug after inhaled administration results in low serum concentrations, and therefore there is modest systemic exposure to zanamivir after inhalation. Zanamivir is not metabolised, and the potential for clinically relevant drug-dr …
Keywords
injections
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
safety
adult
female
male
adolescent
middle aged
Comparative Study
Clinical Trial
Randomized Controlled Trial
Double-Blind Method
reference values
inhalation
antiviral agents / administration & dosage
oral
intravenous
intranasal
guanidines
pyrans
zanamivir
neuraminidase / antagonists & inhibitors
pmid:10429835
doi:10.2165/00003088-199936001-00001
l m cass
c efthymiopoulos
a bye
antiviral agents / pharmacokinetics*
biological availability
sialic acids / administration & dosage
sialic acids / pharmacokinetics*
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270635
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