A common human skin tumour is caused by activating mutations in beta-catenin
Abstract
WNT signalling orchestrates a number of developmental programs. In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family. One of the target genes for beta-catenin/TCF encodes c-MYC, expla …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
amino acid sequence
P.H.S.
DNA
Sequence Analysis
polymerase chain reaction
Molecular Sequence Data
transcription factors / metabolism
mutation*
dna-binding proteins / metabolism
trans-activators*
beta catenin
lymphoid enhancer-binding factor 1
gene frequency
deoxyribonucleases
pmid:10192393
doi:10.1038/7747
e f chan
u gat
e fuchs
cytoskeletal proteins / genetics*
dna-binding proteins / analysis
type ii site-specific / genetics
hair diseases / genetics*
hair diseases / pathology
pilomatrixoma / genetics*
pilomatrixoma / pathology
skin neoplasms / genetics*
skin neoplasms / pathology
transcription factors / analysis
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270505
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