Real-world effectiveness and predictors of sustained virological response with all-oral therapy in 21,242 hepatitis C genotype-1 patients
Abstract
The diversity and size of this cohort allowed for extensive examination of regimen-specific predictors of SVR. FIB-4>3.25 and detectable 4-week on-treatment HCV RNA had the greatest negative impact. African-American race, low or high BMI, and PPIs negatively impacted odds of SVR for LDV/SOF ±RBV. …
Keywords
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
prognosis
treatment outcome
adult
female
male
aged
middle aged
Comorbidity
risk factors
80 and over
drug therapy
combination
hepatitis c / diagnosis
antiviral agents / administration & dosage
antiviral agents / therapeutic use*
oral
hepacivirus / genetics*
hepatitis c / epidemiology
hepatitis c / drug therapy*
sustained virologic response
genotype*
hepatitis c / virology*
lisa i backus
larry a mole
pmid:27934775
doi:10.3851/imp3117
pamela s belperio
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270458
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