Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes
Abstract
Fatty acid uptake into 3T3 L1 adipocytes is predominantly transporter mediated. Here we show that, during 3T3 L1 adipocyte differentiation, expression of fatty acid transport proteins (FATPs) 1 and 4 is induced. Using subcellular membrane fractionation and immunofluorescence microscopy, we demonstra …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
female
male
P.H.S.
Adipocytes / drug effects
Insulin / pharmacology*
Inbred BALB C
adipocytes / metabolism*
cell differentiation / physiology
membrane transport proteins*
tumor necrosis factor-alpha / pharmacology
cell nucleus / metabolism
carrier proteins / metabolism*
hypoglycemic agents / pharmacology*
antineoplastic agents / pharmacology
energy metabolism / physiology
pmid:11970897
doi:10.1016/s1534-5807(02)00143-0
andreas stahl
james g evans
harvey f lodish
3t3 cells / cytology
3t3 cells / metabolism
cell membrane / metabolism
fatty acid transport proteins
fatty acids / pharmacokinetics*
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270457
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