Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade

Ser Sue Ng, Tokameh Mahmoudi, Esther Danenberg, Inés Bejaoui, Wim de Lau, Hendrik C. Korswagen, Mieke Schutte, Hans Clevers;Ser Sue Ng;Tokameh Mahmoudi;Esther Danenberg;Inés Bejaoui;Wim de Lau;Hendrik C. Korswagen;Mieke Schutte;Hans Clevers;
The Journal of biological chemistry 2009 Vol. 284 pp. 35308-
101
clevers2009thephosphatidylinositol

Abstract

Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a wide variety of tumors, whereas activating Wnt pathway mutants are predominantly found in colon cancer. Because GSK3 is a key component of both pathways, it is widely ...

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