The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
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The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research

Marjan Vandenabeele, Lien Veys, Sophie Lemmens, Xavier Hadoux, Géraldine Gelders, Luca Masin, Lutgarde Serneels, Jan Theunis, Takashi Saito, Takaomi C. Saido, Murali Jayapala, Patrick De Boever, Bart De Strooper, Ingeborg Stalmans, Peter van Wijngaarden, Lieve Moons, Lies De Groef;Marjan Vandenabeele;Lien Veys;Sophie Lemmens;Xavier Hadoux;Géraldine Gelders;Luca Masin;Lutgarde Serneels;Jan Theunis;Takashi Saito;Takaomi C. Saido;Murali Jayapala;Patrick De Boever;Bart De Strooper;Ingeborg Stalmans;Peter van Wijngaarden;Lieve Moons;Lies De Groef;
acta neuropathologica communications 2021 Vol. 9 pp. -
171
groef2021actathe

Abstract

In this study, we report the results of a comprehensive phenotyping of the retina of the App[NL-G-F] mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation ...

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DOI:
10.1186/s40478-020-01102-5
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC77889...

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