Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis
Abstract
Taken together, these data demonstrate that elevated DKK-1 expression is an early event in PCa and that as PCa progresses DKK-1 expression declines, particularly in advanced bone metastases. The decline of DKK-1 in bone metastases can unmask Wnts' osteoblastic activity. These data support a model in …
Keywords
biopsy
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
prognosis
research support
male
N.I.H.
Extramural
Retrospective Studies
biomarkers
disease progression
kaplan-meier estimate
beta catenin / metabolism
Intercellular Signaling Peptides and Proteins / metabolism*
bone neoplasms / metabolism
prostatic neoplasms / metabolism*
prostatic neoplasms / pathology
pmid:18561248
pmc3260942
doi:10.1002/pros.20805
christopher l hall
stephanie d daignault
evan t keller
tumor / metabolism*
bone neoplasms / secondary
liver neoplasms / metabolism
liver neoplasms / secondary
lung neoplasms / metabolism
lung neoplasms / secondary
neoplasm metastasis*
prostatic neoplasms / diagnosis
soft tissue neoplasms / secondary
tissue array analysis
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270207
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