Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies
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Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies

Connor Bargar, Wen Wang, Steven A. Gunzler, Alexandra LeFevre, Zerui Wang, Alan J. Lerner, Neena Singh, Curtis Tatsuoka, Brian Appleby, Xiongwei Zhu, Rong Xu, Vahram Haroutunian, Wen-Quan Zou, Jiyan Ma, Shu G. Chen;Connor Bargar;Wen Wang;Steven A. Gunzler;Alexandra LeFevre;Zerui Wang;Alan J. Lerner;Neena Singh;Curtis Tatsuoka;Brian Appleby;Xiongwei Zhu;Rong Xu;Vahram Haroutunian;Wen-Quan Zou;Jiyan Ma;Shu G. Chen;
acta neuropathologica communications 2021 Vol. 9 pp. -
105
chen2021actastreamlined

Abstract

Definitive diagnosis of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) relies on postmortem finding of disease-associated alpha-synuclein (αSyn[D] ) as misfolded protein aggregates in the central nervous system (CNS). The ...

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DOI:
10.1186/s40478-021-01175-w
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC80280...

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