Interrogating open issues in cancer precision medicine with patient-derived xenografts
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Interrogating open issues in cancer precision medicine with patient-derived xenografts

Byrne AT;Alférez DG;Amant F;Annibali D;Arribas J;Biankin AV;Bruna A;Budinská E;Caldas C;Chang DK;Clarke RB;Clevers H;Coukos G;Dangles-Marie V;Eckhardt SG;Gonzalez-Suarez E;Hermans E;Hidalgo M;Jarzabek MA;de Jong S;Jonkers J;Kemper K;Lanfrancone L;Mælandsmo GM;Marangoni E;Marine JC;Medico E;Norum JH;Palmer HG;Peeper DS;Pelicci PG;Piris-Gimenez A;Roman-Roman S;Rueda OM;Seoane J;Serra V;Soucek L;Vanhecke D;Villanueva A;Vinolo E;Bertotti A;Trusolino L;;
Nature reviews. Cancer 2017 Vol. 17 pp. -
249
at2017natureinterrogating

Abstract

Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolu …

Keywords

National Center for Biotechnology Information NCBI NLM MEDLINE Mice review animals clinical trials as topic humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural Disease Models Animal neoplasms / pathology drug resistance immunotherapy biomarkers neoplasms / therapy* neoplasm metastasis tumor / analysis neoplasm pmid:28104906 doi:10.1038/nrc.2016.140 annette t byrne denis g alférez livio trusolino neoplastic stem cells / physiology precision medicine* xenograft model antitumor assays*

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