A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin
Abstract
Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin (BoNT) on nerve cells. There are 7 known serotypes (A-G) of BoNT and up to 40 genetic variants. Clostridium botulinum strain IBCA10-7060 was recently reported to produce BoNT serotype B (BoNT/B) and a nove …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
N.I.H.
Extramural
P.H.S.
pmid:26068781
pmc4704661
doi:10.1093/infdis/jiv327
susan e maslanka
carolina lúquez
eric a johnson
biological assay
botulinum antitoxin / pharmacology*
botulinum toxins / chemistry*
botulinum toxins / classification*
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