Endosomal cAMP production broadly impacts the cellular phosphoproteome

Endosomal cAMP production broadly impacts the cellular phosphoproteome

Tsvetanova NG;Trester-Zedlitz M;Newton BW;Peng GE;Johnson JR;Jimenez-Morales D;Kurland AP;Krogan NJ;von Zastrow M;;
The Journal of biological chemistry 2021 Vol. 297 pp. -
136
ng2021theendosomal

Abstract

Endosomal signaling downstream of G-protein-coupled receptors (GPCRs) has emerged as a novel paradigm with important pharmacological and physiological implications. However, our knowledge of the functional consequences of intracellular signaling is incomplete. To begin to address this gap, we combin …

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