A novel method for SNP detection using a new duplex-specific nuclease from crab hepatopancreas
Abstract
We have characterized a novel nuclease from the Kamchatka crab, designated duplex-specific nuclease (DSN). DSN displays a strong preference for cleaving double-stranded DNA and DNA in DNA-RNA hybrid duplexes, compared to single-stranded DNA. Moreover, the cleavage rate of short, perfectly matched DN …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
animals
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
Molecular Sequence Data
Polymorphism
endonucleases / genetics*
cloning
single nucleotide / genetics*
liver / enzymology
pmid:12466298
pmc187582
doi:10.1101/gr.547002
dmitry a shagin
denis v rebrikov
sergey lukyanov
anomura / enzymology*
anomura / genetics*
molecular / methods
nucleic acid heteroduplexes / genetics*
oligonucleotides / chemical synthesis
oligonucleotides / metabolism
pancreas / enzymology
substrate specificity / genetics
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269716
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