Adrenergic Downregulation in Critical Care: Molecular Mechanisms and Therapeutic Evidence
Abstract
Catecholamines remain the mainstay of therapy for acute cardiovascular dysfunction. However, adrenergic receptors quickly undergo desensitization and downregulation after prolonged stimulation. Moreover, prolonged exposure to high circulating catecholamines levels is associated with several adverse …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
humans
pubmed abstract
nih
national institutes of health
national library of medicine
critical care
down-regulation
Vasoconstrictor Agents / therapeutic use
pmid:31839459
doi:10.1053/j.jvca.2019.10.017
alessandro belletti
giovanni landoni
silvia ajello
adrenergic agents*
catecholamines
shock*
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ID:
269690
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