Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells

Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells

David Y. Takeda, Yoshiyuki Shibata, Jeffrey D. Parvin, Anindya Dutta;David Y. Takeda;Yoshiyuki Shibata;Jeffrey D. Parvin;Anindya Dutta;
genes & development 2005 Vol. 19 pp. 2827-
107
dutta2005genesrecruitment

Abstract

Origins of replication are expected to recruit initiation proteins like origin recognition complex (ORC) and Cdc6 in eukaryotes and provide a platform for unwinding DNA. Here we test whether localization of initiation proteins onto DNA is sufficient for ...

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269644
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10.1101/gad.1369805
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