Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells
David Y. Takeda, Yoshiyuki Shibata, Jeffrey D. Parvin, Anindya Dutta;David Y. Takeda;Yoshiyuki Shibata;Jeffrey D. Parvin;Anindya Dutta;
genes & development2005Vol. 19pp. 2827-
107
dutta2005genesrecruitment
Abstract
Origins of replication are expected to recruit initiation proteins like origin recognition complex (ORC) and Cdc6 in eukaryotes and provide a platform for unwinding DNA. Here we test whether localization of initiation proteins onto DNA is sufficient for ...