Novel Ligands Balance Estrogen Receptor β and α Agonism for Safe and Effective Suppression of the Vasomotor Response in the Ovariectomized Female Rat Model of Menopause
McGregor, Chelsea;Sau, Andrea;Ruddy, Samantha C.;Leung, Dan;Webb, Murray;Durst, Tony;Wright, James S.;Lagace, Diane;Pratt, M.A. Christine;
endocrinology2014Vol. 155pp. 2480-2491
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chelsea2014endocrinologynovel
Abstract
Vasomotor thermo-dysregulation (hot flashes) are an often debilitating symptom of menopause. Effective treatment is achieved primarily through activation of the