C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation
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C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto, Koichi Ichimura;Tatsuya Ozawa;Syuzo Kaneko;Frank Szulzewsky;Zhiwei Qiao;Mutsumi Takadera;Yoshitaka Narita;Tadashi Kondo;Eric C. Holland;Ryuji Hamamoto;Koichi Ichimura;
acta neuropathologica communications 2021 Vol. 9 pp. -
119
ichimura2021actac11orf95-rela

Abstract

Recurrent C11orf95-RELA fusions (RELA[FUS] ) are the hallmark of supratentorial ependymomas. The presence of RELA as the fusion partner indicates a close association of aberrant NF-κB activity with tumorigenesis. However, the oncogenic role of ...

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DOI:
10.1186/s40478-021-01135-4
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79417...

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