Pharmacokinetic-Pharmacodynamic Considerations in the Design of Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia Studies: Look before You Leap!
Ambrose, Paul G.;Bhavnani, Sujata M.;Grosse, Evelyn J. Ellis;Drusano, George L.;
Abstract. Our thesis is a simple one: although a drug can fail in an individual patient for many reasons, appropriately sized and conducted drug-development pro