Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis

Könner AC;Hess S;Tovar S;Mesaros A;Sánchez-Lasheras C;Evers N;Verhagen LA;Brönneke HS;Kleinridders A;Hampel B;Kloppenburg P;Brüning JC;;
cell metabolism 2011 Vol. 13 pp. -
344
ac2011cellrole

Abstract

Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydroxylase (Th)-expressing cells of mice ( …

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