National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice gene expression regulation animals humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't P.H.S. Cultured cell line mutation transcription transfection tumor cells nuclear proteins* proteasome endopeptidase complex proto-oncogene proteins / metabolism* proto-oncogene proteins c-mdm2 tumor suppressor protein p53 / metabolism* proto-oncogene proteins / genetics pmid:9153396 doi:10.1038/387299a0 m h kubbutat s n jones k h vousden acetylcysteine / analogs & derivatives acetylcysteine / pharmacology cysteine endopeptidases / metabolism cysteine proteinase inhibitors / pharmacology multienzyme complexes / metabolism tumor suppressor protein p53 / genetics