AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
Abstract
The central melanocortin (MC) system has been demonstrated to act downstream of leptin in the regulation of body weight. The system comprises alpha-MSH, which acts as agonist, and agouti-related protein (AgRP), which acts as antagonist at the MC3 and MC4 receptors (MC3R and MC4R). This property sugg …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
Receptors
proteins / pharmacology*
receptor
agouti-related protein
intercellular signaling peptides and proteins
peptide fragments / pharmacology*
pmid:11145747
doi:10.1210/mend.15.1.0578
w a nijenhuis
j oosterom
r a adan
adenylyl cyclases / metabolism
colforsin / pharmacology
melanocortin
type 4
corticotropin / agonists*
corticotropin / drug effects*
corticotropin / physiology
alpha-msh / pharmacology
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269231
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