A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation properties
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) continues to circulate in both humans and camels, and the origin and evolution of the virus remain unclear. Here we characterize the spike protein of a camel-derived MERS-CoV (NRCE-HKU205) identified in 2013, early in the MERS outbreak. NRCE-HK …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
cell line
pmid:27999426
pmc5180369
doi:10.1038/emi.2016.125
jean kaoru millet
monty e goldstein
gary r whittaker
amino acid substitution*
camelus / virology*
furin / metabolism
isoleucine / genetics
middle east respiratory syndrome coronavirus / genetics*
middle east respiratory syndrome coronavirus / isolation & purification*
middle east respiratory syndrome coronavirus / physiology
proteolysis
serine / genetics
spike glycoprotein
coronavirus / genetics*
coronavirus / metabolism
virus internalization
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269221
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269221
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