POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

Jeffrey Zheng-Sheng Ye, Dirk Hockemeyer, Andrew N. Krutchinsky, Diego Loayza, Sarah M. Hooper, Brian T. Chait, Titia de Lange;Jeffrey Zheng-Sheng Ye;Dirk Hockemeyer;Andrew N. Krutchinsky;Diego Loayza;Sarah M. Hooper;Brian T. Chait;Titia de Lange;
genes & development 2004 Vol. 18 pp. 1649-
121
lange2004genespot1-interacting

Abstract

Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. ...

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