Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis

Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis

Quezada G;Koshkina NV;Zweidler-McKay P;Zhou Z;Kontoyiannis DP;Kleinerman ES;;
Antimicrobial agents and chemotherapy 2008 Vol. 52 pp. -
247
g2008antimicrobialintranasal

Abstract

We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-tar …

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