IL-6 as a keystone cytokine in health and disease - Nature Immunology
Hunter, Christopher A;Jones, Simon A;Hunter, Christopher A;Jones, Simon A;
Nature Immunology2015Vol. 16pp. 448-457
293
a2015natureil-6
Abstract
IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. Hunter and Jones discuss the effect of IL-6 on innate and adaptive immunity, and consider how the immunobiology of IL-6 may inform clinical decisions.