Determination of the pH of the Cryptococcus neoformans vacuole
Abstract
We have previously demonstrated the antifungal activity of the weak bases chloroquine and quinacrine against Cryptococcus neoformans. Quinacrine, being fluorescent, was seen to be concentrated within a complex vacuolar structure within the cryptococcal cell. Here we determined the pH of this compart …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
microscopy
fluorescence
hydrogen-ion concentration
fluoresceins
pmid:12146766
doi:10.1080/mmy.40.3.329.332
t s harrison
j chen
s m levitz
cryptococcus neoformans / chemistry*
cryptococcus neoformans / ultrastructure
confocal
vacuoles / chemistry*
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269169
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