Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling
Abstract
Loss of tissue organization is a hallmark of the early stages of cancer, and there is considerable interest in proteins that maintain normal tissue architecture. Prostate epithelial cells cultured in Matrigel form three-dimensional acini that mimic aspects of prostate gland development. The organiza …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
cell line
Knockout
immunohistochemistry
blotting
western
morphogenesis / genetics
adaptor proteins
signal transducing
smad proteins / genetics
transforming growth factor beta / genetics
transforming growth factor beta / metabolism*
pmid:23444370
doi:10.1242/jcs.119388
Diana Romero
Yoshiaki Kawano
Robert Kypta
Intercellular Signaling Peptides and Proteins / genetics
Intercellular Signaling Peptides and Proteins / metabolism*
Morphogenesis / physiology*
Prostate / cytology*
Prostate / metabolism*
Smad Proteins / metabolism*
Citation
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269147
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