Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
Abstract
Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Emu) develop B-cell lymphoma and exhibit a mean survival time of approximately 6 months. The protracted latent period before the onset of frank disease likely reflects the ability of c-Myc to induce a p5 …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
female
male
P.H.S.
Cells
Cultured
Genes
enhancer elements
mutation
Knockout
lymphoma
proteins / genetics*
hematopoietic stem cells / cytology
transgenic
apoptosis / genetics
proto-oncogene proteins / genetics*
nuclear proteins*
C M Eischen
myc*
p53*
Tumor Suppressor Protein p14ARF
proto-oncogene proteins c-mdm2
b-cell / etiology*
b-cell / genetics*
b-cell / pathology
pmid:10541552
pmc317106
doi:10.1101/gad.13.20.2658
j d weber
j l cleveland
b-lymphocytes / cytology
immunoglobulin heavy chains / genetics
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269096
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