Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease
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Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Valentina Latina, Giacomo Giacovazzo, Federica Cordella, Bijorn Omar Balzamino, Alessandra Micera, Monica Varano, Cristina Marchetti, Francesca Malerba, Rita Florio, Bruno Bruni Ercole, Federico La Regina, Anna Atlante, Roberto Coccurello, Silvia Di Angelantonio, Pietro Calissano, Giuseppina Amadoro;Valentina Latina;Giacomo Giacovazzo;Federica Cordella;Bijorn Omar Balzamino;Alessandra Micera;Monica Varano;Cristina Marchetti;Francesca Malerba;Rita Florio;Bruno Bruni Ercole;Federico La Regina;Anna Atlante;Roberto Coccurello;Silvia Di Angelantonio;Pietro Calissano;Giuseppina Amadoro;
acta neuropathologica communications 2021 Vol. 9 pp. -
78
amadoro2021actasystemic

Abstract

Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic ...

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DOI:
10.1186/s40478-021-01138-1
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79420...

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