Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys
Abstract
Experimentally induced fetal androgen excess induces polycystic ovary syndrome-like traits in adult female rhesus monkeys (Macaca mulatta). Developmental changes leading to this endocrinopathy are not known. We therefore studied 15 time-mated, gravid female rhesus monkeys with known female fetuses. …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
female
N.I.H.
Extramural
david h abbott
alice f tarantal
luteinizing hormone / blood
polycystic ovary syndrome / chemically induced*
newborn
macaca mulatta
polycystic ovary syndrome / physiopathology
progesterone / blood
androgens / pharmacology*
polycystic ovary syndrome / embryology
fetus / drug effects*
polycystic ovary syndrome / pathology
estrogens / blood
pmid:18385445
pmc2531213
doi:10.1095/biolreprod.108.067702
deborah k barnett
androgens / blood
birth weight / drug effects
endocrine system / physiopathology*
fetus / pathology
prenatal exposure delayed effects / blood
prenatal exposure delayed effects / chemically induced*
prenatal exposure delayed effects / pathology
prenatal exposure delayed effects / physiopathology
prenatal exposure delayed effects / veterinary
virilism / blood
virilism / chemically induced*
virilism / pathology
virilism / physiopathology
Citation
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269066
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