Pharmaceuticals and personal care products (PPCPs) is an important class of environmental contaminants and has gained increasing concerns in recent years. The bioaccumulation behaviour of PPCPs in wetland plants is not well understood. In the present study we report results of a field investigation to assess the bioaccumulation behaviour and phytoremediation efficacy of several PPCPs in Lorong Halus Wetland, a large-scale constructed wetland system in Singapore, constructed for the treatment of landfill leachate. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods were employed to quantify concentrations of target PPCPs in leachate and flowing water, as well as wetland plants (roots and shoots), at different locations in the wetland system. The results indicated the presence of several PPCPs in leachate, water and vegetation in the wetland. Bioconcentration factors (BCFs) in the dominant wetland plant, Typha angustifolia, ranged between approximately 60 and 2000. Results indicated that Cattail Typha angustifolia was capable of remediating PPCPs to various extends, with bioconcentration factors ranging up to 2000. The suitability for phytoremediation depends on the physical chemical properties such as hydrophilicity and lipophilicity of these PPCPs.