Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators
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Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

Huppertsberg A;Kaps L;Zhong Z;Schmitt S;Stickdorn J;Deswarte K;Combes F;Czysch C;De Vrieze J;Kasmi S;Choteschovsky N;Klefenz A;Medina-Montano C;Winterwerber P;Chen C;Bros M;Lienenklaus S;Sanders NN;Koynov K;Schuppan D;Lambrecht BN;David SA;De Geest BG;Nuhn L;;
Journal of the American Chemical Society 2021 Vol. 143 pp. -
190
a2021journalsquaric

Abstract

Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-control inflammatory off-target effects, their appli …

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National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine pmid:34166595 pmc8267846 doi:10.1021/jacs.1c03772 anne huppertsberg leonard kaps lutz nuhn

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