Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
Abstract
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R), was originally purified from the rat stomach. Like the synthetic growth hormone secretagogues (GHSs), ghrelin specifically releases growth hormone (GH) after intravenous administration. Also consistent with the centr …
Keywords
injections
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Drug Administration Schedule
Rats
Sprague-Dawley
proteins / genetics*
messenger / metabolism*
hypothalamus / metabolism*
gene expression / drug effects
pmid:11679419
doi:10.2337/diabetes.50.11.2438
j kamegai
h tamura
i wakabayashi
agouti-related protein
body weight / drug effects*
eating / drug effects
ghrelin
hypothalamus / drug effects
intraventricular
intercellular signaling peptides and proteins
neuropeptide y / metabolism*
peptide hormones*
peptides / administration & dosage*
peptides / pharmacology
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