Single-molecule sequencing of an individual human genome
Abstract
Recent advances in high-throughput DNA sequencing technologies have enabled order-of-magnitude improvements in both cost and throughput. Here we report the use of single-molecule methods to sequence an individual human genome. We aligned billions of 24- to 70-bp reads (32 bp average) to approximatel …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
reproducibility of results
research support
u.s. gov't
non-p.h.s.
N.I.H.
Extramural
Sequence Analysis
genome
genomics / methods*
Polymorphism
DNA / methods*
computer simulation
single nucleotide
human*
pmid:19668243
pmc4117198
doi:10.1038/nbt.1561
dmitry pushkarev
norma f neff
stephen r quake
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268757
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