SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
Wang X;Sato R;Brown MS;Hua X;Goldstein JL;;
Cell1994Vol. 77pp. -
278
x1994cellsrebp-1,
Abstract
Sterol regulatory element-binding protein 1 (SREBP-1), a member of the basic-helix-loop-helix-leucine zipper (bHLH-ZIP) family of transcription factors, is synthesized as a 125 kd precursor that is attached to the nuclear envelope and endoplasmic reticulum. In sterol-depleted cells, the membrane-bou …